International Review of Ophthalmology ›› 2014, Vol. 38 ›› Issue (5): 309-315.doi: 10.3760/ cma. j. issn.1673-5803.2014.05.005

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Clinical application of visual electrophysiology technique in glaucoma

AN Jing, ZHANG Zuo-ming.   

  1. Department of Aerospace Clinical Medicine, Fourth Military Medical University, Xi'an 710032, China
  • Received:2014-02-18 Online:2014-10-22 Published:2014-10-24
  • Contact: ZHANG Zuo-ming, Email: zhangzm@fmmu.edu.cn

Abstract: The visual electrophysiological techniques, such as pattern electroretinogram (PERG), photopic negative response (PhNR), multifocal electroretinogram (mfERG) and multifocal visual evoked potential (mfVEP), scotopic threshold response (STR), were applied to evaluate changes in each stage of the course of glaucoma. And these methods could provide help for the early diagnosis of it. PERG, PhNR can directly reflect the function of retinal ganglion cells (RGC) and optic nerve. PERG is the most sensitive indicator, the response changes are detected in suspected glaucoma. Recently the evaluation of damage degree of RGC could be shown by PhNR. Secondorder kernel mfERG be used to evaluate the spatial distribution of RGC function, the response is similar to the result of visual field. MfVEP is a sensitive index for patients with visual field loss. STR requires rigorous stimulation conditions; the current results show that the STR is not a sensitive index to glaucoma patients compared with other visual electrophysiological techniques.  (Int Rev Ophthalmol, 2014, 38:   309-315)